Conditions
Prediabetes is often part of a bigger picture.
Blood sugar, insulin, weight, hormones, cholesterol, blood pressure and liver health can be connected through the way our bodies produce and respond to insulin. Understanding those connections can make confusing diagnoses and lab results easier to understand.
Here you’ll find clear, evidence-based information about prediabetes and related metabolic conditions—what they are, how they are diagnosed, how they may be connected, and what current research tells us about managing them.
Prediabetes
Blood sugar is higher than normal, but not yet in the range used to diagnose diabetes. Learn what a prediabetes diagnosis means, how it is measured, what increases risk, and what you may be able to do about it.
Explore Prediabetes →
Insulin Resistance
Insulin helps move glucose from the bloodstream into cells where it can be used for energy. Insulin resistance occurs when the body’s cells don’t respond to insulin as effectively as they should. Learn why this happens and how it relates to prediabetes and other metabolic conditions.
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Type 2 Diabetes
Type 2 diabetes develops when the body can no longer maintain normal blood glucose levels adequately. Learn about diagnosis, monitoring, treatment, lifestyle and living well with type 2 diabetes.
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Metabolic Syndrome
Metabolic syndrome isn’t a single disease. It describes a group of metabolic risk factors that occur together and increase the risk of conditions including type 2 diabetes and cardiovascular disease.
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PCOS / PMOS
Polycystic ovary syndrome (PCOS) is a hormonal and metabolic disorder, and insulin resistance is common among people who have it. Learn about the relationship between PCOS, insulin, blood sugar, weight and long-term metabolic health.
Explore PCOS / PMOS →
Gestational Diabetes
Gestational diabetes develops during pregnancy. Although it usually resolves after pregnancy, having had gestational diabetes is an important indicator of future metabolic health and an increased risk for developing type 2 diabetes.
Explore Gestational Diabetes →
Fatty Liver (MASLD)
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly commonly called nonalcoholic fatty liver disease or NAFLD, involves excess fat accumulating in the liver and is closely associated with metabolic health.
Explore Fatty Liver (MASLD) →
A note about health information
Pre-Diabetes.com provides general educational information, not individual medical advice. Medical conditions can have many causes and may require individualized diagnosis and treatment. Discuss concerns about your health, medications or treatment with a qualified healthcare professional.
Sources & Further Reading
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Symptoms & Causes of Diabetes
Explains insulin resistance, the role of insulin and the relationship among insulin resistance, prediabetes and type 2 diabetes.
https://www.niddk.nih.gov/health-information/diabetes/overview/symptoms-causes
American Diabetes Association
Prevention or Delay of Diabetes and Associated Comorbidities: Standards of Care in Diabetes—2026
Current evidence and recommendations concerning lifestyle intervention, nutrition and physical activity for people with prediabetes and increased diabetes risk.
https://diabetesjournals.org/care/article/49/Supplement_1/S50/163924/3-Prevention-or-Delay-of-Diabetes-and-Associated
American Diabetes Association
Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes: Standards of Care in Diabetes—2026
Current recommendations concerning individualized nutrition, physical activity and other health behaviors for people with prediabetes and diabetes.
https://diabetesjournals.org/care/article/49/Supplement_1/S89/163932/5-Facilitating-Positive-Health-Behaviors-and-Well
Sources & Further Reading
American Diabetes Association
Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2026
Current information about prediabetes, diabetes risk factors and conditions associated with insulin resistance.
https://diabetesjournals.org/care/article/49/Supplement_1/S27/163926/2-Diagnosis-and-Classification-of-Diabetes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diagnosis of NAFLD & NASH
Information about metabolic dysfunction-associated steatotic liver disease (MASLD), formerly commonly called NAFLD, and its relationship to insulin resistance, diabetes, abnormal blood lipids and metabolic syndrome.
https://www.niddk.nih.gov/health-information/liver-disease/nafld-nash/diagnosis
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Polycystic Ovary Syndrome (PCOS)
Information about PCOS and associated conditions including insulin resistance, metabolic syndrome, prediabetes and type 2 diabetes.
https://www.nichd.nih.gov/health/topics/factsheets/pcos