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Pre-Diabetes

Pre-diabetes Illustrated Medical Encyclopedia


 

Filed in: Pre-Diabetes Medical Encyclopedia

Definition: Acanthosis Nigricans (AN)

 

What is acanthosis nigricans?

Acanthosis nigricans (AN) is (usually) a benign skin condition typically characterized by hyperpigmentation (darkening of skin pigment) often accompanied by a velvety change in texture of the skin that is affected.

Acanthosis nigricans is often seen in obese patients with insulin resistance which is often associated with pre-diabetes and type 2 diabetes.

If you see changes in skin color or texture it is important to see your doctor.  A dermatologist may be able to diagnose acanthosis nigricans, but to diagnose insulin resistance you should see an endocrinologist.

 

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If you have pre-diabetes, insulin resistance, metabolic syndrome, PCOS, or impaired glucose tolerance you need to take it seriously.  If you do not - it will get worse.

 

 

What parts of the body does acanthosis nigricans affect?

It most commonly appears in body folds like under the arms, groin, and back of the knees. But AN can appear almost anywhere on the body including the scalp, hands, elbows, and nipples.

What causes acanthosis nigricans?

AN is most often caused by hyperinsulinemia (elevated levels of insulin) due to insulin resistance. AN is most commonly seen in obese people but can occur in any patient that is insulin resistant.

AN may be diagnosed by a dermatologist when a patient mistakes AN for another skin condition. AN is almost always benign (non-cancerous) but in rare cases can be serious. Skin tags often appear in the same patients who have AN.

 

Acanthosis nigricans on the nape of the neck
Acanthosis Nigricans on Nape of Neck

A milder case of acanthosis nigricans (AN) on the nape of the neck. AN can also appear on the groin, under breasts, chest, and even on the scalp.

Picture of acanthosis nigricans in the arm pit
Underarm AN

Acanthosis nigricans in the underarm area may become quite dark but can also appear like a mild, yellowish-tan stain.

Picture of acanthosis nigricans on the elbow
Acanthosis Nigricans
on the Elbow

 

AN can sometimes appear on the elbows (or knees). It may even be mistaken for psoriasis or appear in conjunction with psoriasis.

Picture of acanthosis nigricans on the hand

Acanthosis Nigricans
on the Hand

 

AN can also appear on the palms and back of the hands.  It may even be mistaken for psoriasis or appear in conjunction with psoriasis.

 

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